When I performed Cryotherapy for the full prostatic gland or only one lobe, I froze the gland to -20 to -40 Centigrade, and according the size of the prostate, it took 8-10 minutes to complete. Then, I prefer to keep frozen for one additional minute before defrosting ( thawing ) the gland, which it takes approximately the same time as freezing. Then I did a second cycle of freezing-thawing similar to the first one.

 My results of the biopsies at 6 months post-Cryo, showed in the 10-12 needle biopsies no more evidence of cancer cells, just Fibrosis, with 97 % of patients free of localized cancer. The other 3 % showed still cancer, of lower Gleason’ score, in few of the post Cryo biopsies and the majority of these were early in my curve of learning how properly to freeze the prostatic gland.

In all my patients with high Gleason scores of 8-10, with visible or not ( microscopic ) distant metastasis, I placed them after Cryo, for one year of hormonal deprivation of Testosterone. This regimen resulted in good survival at 4-to more of 5 years post Cryo, with PSA of less 0.5 ng/ml in patients with Gleson’s score of 8 and 9, and just close to one year in a patient with Gleason’s score of 10.